Table 4. “Jackknifing” the HML HMM: Removing one group of the training set and detecting the group removed in chromosome 19.
Model | no_hml1 | no_hml2 | no_hml3 | no_hml4 | no_hml5 | no_hml6 | no_hml7 | no_hml8 | no_hml9 | no_hml10 |
# match states | 130 | 170 | 110 | 130 | 110 | 110 | 130 | 110 | 210 | 170 |
Threshold | 5 | 5 | 6 | 5 | 5 | 5 | 6 | 5 | 6 | 5 |
Sensitivity (including removed group) (%) | 60 | 87 | 62 | 78 | 70 | 82 | 80 | 74 | 87 | 87 |
Specificity (%) | 91 | 96 | 93 | 95 | 91 | 91 | 91 | 93 | 86 | 91 |
% detection of removed hml group | 52 | 88 | 6 | 83 | 0 | 59 | 71 | 23 | 67 | 67 |