A schematic drawing depicting possible steps where fabaceous small GTPases couldplay role during the development and maintenance of nodules. The dashed arrows indicate the possible addresses of the vesicle-coated cargo and the questions marks limn the locations where small GTPases, identified by us could involve in the regulation of the nodule-specific trafficking. The abbreviations: PM, Plasma Membrane; PBM, Peribacteroid Membrane; CW, Cell Wall; and ER, Endoplasmic Reticulum.