Table 1.
Karyotypic abnormalities of myc in MM cell lines
| Cell line | Chr | A | N | Abnormality |
|---|---|---|---|---|
| ARK | 46 | 1 | 1 | t(8;14) classic:der(14) and der(8) |
| *FR4 | 100 | 2 | 3 | t(8;14) classic;der(14) and der(8) |
| LP1 | 80 | 5 | 1 | t(8;14) variant:der(8) with VH |
| SK-MM1 | 79 | 4 | 0 | t(8;14) variant: der(8) without VH |
| KMS-12PE | 47 | 2† | 1 | CH insertion with duplication of c-myc and CH on 8 |
| KMS-12BM | 77 | 8† | 3 | CH insertion with duplication of c-myc and CH on 8 |
| *MM-S1 | 47 | 6† | 1 | CH insertion with duplication of c-myc and CH on 8 |
| *MM.1 | 44 | 1 | 1 | CH insertion on t(3;8)(q21;q24):der(3) |
| *OPM-1 | 74 | 2 | 2 | CH insertion on t(1;8)(q12?;q24):der(8) |
| *OPM-2 | 67 | 2 | 2 | CH insertion on t(1;8)(q12?;q24):der(8) |
| *KMS-11 | 70 | 2† | 3 | CH+c-myc insertion and duplication on ? |
| OCI-MY5 | 46 | 2† | 1 | CH+c-myc insertion and duplication on ? |
| KMM-1 | 80 | 2 | 3 | c-myc insertion on 14 |
| *JJN3 | 60 | 3 | 2 | CH insertion on 8 and CH insertion on t(8;14)(q24;p?):der(14) |
| KARPAS 620 | 68 | 4 | 2 | t(8;14)classic:der(14) and CH insertion on t(8;11):der(8) |
| 8226 | 60 | 1 | 3 | c-myc insertion on t(16;22)(q23;q11):der(16) |
| DELTA-47 | 45 | 2 | 2 | Cλ insertion on t(?;8):der(?) |
| *H929 | 45 | 2 | 1 | t(8;20)(q24;?):der(8) |
| L363 | 46 | 2 | 1 | t(5;8)(q11.2;q32):der(8) |
| *FLAM-76 | 42 | 1 | 1 | c-myc insertion on ? |
| ‡U266 | 39 | 0 | 2 | None |
| L-myc | 1 | 1 | inv(1)(p13;p34) | |
| H112 | 46 | 0 | 2 | None |
The cell lines are separated in accord with the five groups of abnormalities described in the text. For KMS-12 and OPM, there are two independent cell lines from the same tumor. Total chromosome number (Chr) and the number of karyotypically abnormal (A) and normal (N) c-myc alleles are listed (L-myc alleles also are listed for U266 only). For translocations, all derivative chromosomes that were detected are noted. If both derivative chromosomes were detected, the one containing c-myc is listed first. Karyotypic abnormalities that are far from c-myc are not described here or in the text.
Selective expression of one c-myc allele.
Includes duplication of c-myc and CH on each abnormal chromosome.
Expression of L-myc only.