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. 2009 Mar 11;29(10):3206–3219. doi: 10.1523/JNEUROSCI.4514-08.2009

Figure 7.

Figure 7.

NMDAR/PKC-dependent mechanical hypersensitivity and dorsal horn GluR2 internalization on days 1 and 3 after CFA. Intrathecal infusion of Chy (A) or APV (B) for 1 d beginning 1 h before CFA injection attenuated CFA-induced ipsilateral mechanical hypersensitivity. **p < 0.01 versus the saline + vehicle group; #p < 0.05 versus the CFA + vehicle group. Intrathecal infusion of Chy (C) or APV (D) for 1 d beginning 1 h before CFA injection abolished CFA-induced increases in the amount of GluR2 in the 150 k-g fraction. **p < 0.01 versus the saline + vehicle group; ##p < 0.01 versus the CFA + vehicle group. Intrathecal infusion of APV and Chy for 1 d beginning on day 2 after CFA reduced CFA-induced mechanical hypersensitivity (E) and increased the amount of GluR2 in the 150 k-g fraction (F). **p < 0.01 versus the vehicle + saline group; #p < 0.05, ##p < 0.01 versus the vehicle + CFA group.