Table 1.
Conserved helicase motif function
| Motif | Function |
|---|---|
| I (yellow) | amino group of lysine interacts with phosphates of MgATP/MgADP; hydroxyl of serine or threonine coordinates Mg2+ ion. |
| Ia (red) | interacts with ssDNA, |
| II (green) | aspartic acid in position 1 coordinates Mg2+ |
| III (purple) | interacts with ATP |
| IV (blue) | interacts with ATP |
| V (turquoise) | interacts with ssDNA and/or ATP |
| VI (brown) | interacts with ATP |
a
Caruthers and McKay, (2002) Curr. Opin. Struct. Biol. 12, 123-133., Korolev et al. (1998) Protein Science 7, 605-610., Phillips et al. (1997) Mol. Gen. Genet. 254, 319-329.