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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Ann Thorac Surg. 2008 Oct;86(4):1268–1276. doi: 10.1016/j.athoracsur.2008.04.107

Table 1.

Serial Changes in Echocardiographically Derived Variables and Infarct Expansion After Myocardial Infarction: Effects of Saline or Fibrin-Alginate Injection at 7 Days After Myocardial Infarction

Time Postmyocardial Infarction (days) p Values from Analysis of Variance
Variable Baseline 7 14 21 28 Within Group (Time) Between Group Interaction
Heart rate, beats/min
  Saline 119 ± 6 117 ± 8 116 ± 4 118 ± 2 129 ± 24 NS … …
  Fibrin-alginate 130 ± 9 123 ± 4 135 ± 6 123 ± 4 121 ± 7
Posterior wall thickness at end-systole, cm
  Saline 1.10 ± 0.05 0.73 ± 0.08a 0.69 ± 0.07a 0.73 ± 0.09a 0.67 ± 0.08a 0.004 0.001 0.228
  Fibrin-alginate 1.13 ± 0.04 0.80 ± 0.06a 1.07 ± 0.11bc 0.90 ± 0.12 0.86 ± 0.11a
Septal wall thickness at end-systole, cm
  Saline 1.10 ± 0.03 1.05 ± 0.03 1.09 ± 0.05 1.18 ± 0.05b 1.23 ± 0.07ab 0.001 0.625 0.914
  Fibrin-alginate 1.04 ± 0.03 1.05 ± 0.04 1.10 ± 0.03 1.19 ± 0.04ab 1.20 ± 0.04ab
End-diastolic volume, mL
  Saline 47.5 ± 2.1 55.3 ± 1.9a 59.4 ± 1.5a 69.9 ± 2.2ab 75.6 ± 3.2ab <0.001 0.274 0.494
  Fibrin-alginate 45.3 ± 1.0 55.5 ± 1.6a 62.1 ± 2.7a 64.9 ± 2.9ab 71.7 ± 3.9ab
Ejection fraction (%)
  Saline 67.0 ± 0.9 53.2 ± 1.1a 49.8 ± 1.6a 47.0 ± 1.9ab 45.6 ± 3.2ab <0.001 0.20 0.983
  Fibrin-alginate 68.1 ± 1.0 54.7 ± 1.7a 51.2 ± 1.2a 48.2 ± 3.8ab 49.0 ± 2.6a
LV mass/body weight, g/kg
  Saline 4.4 ± 0.4 4.2 ± 0.3 3.8 ± 0.3 3.8 ± 0.3 3.5 ± 0.2 NS … …
  Fibrin-alginate 3.7 ± 0.6 3.6 ± 0.5 3.6 ± 0.5 3.1 ± 0.4 3.4 ± 0.5
End-diastolic marker area,
   infarct expansion, cm2
  Saline 1.00 ± … 1.21 ± 0.05 1.11 ± 0.07 1.42 ± 0.08a 1.71 ± 0.13ab 0.018 0.322 0.320
  Fibrin-alginate 1.00 ± … 1.25 ± 0.10 1.22 ± 0.16 1.18 ± 0.17 1.44 ± 0.23a
Change in marker area from 7
   days post-MI, mm2
  Saline … 0 −9.2 ± 9.0 21.4 ± 9.0b 50.6 ± 14.0b 0.072 0.018 0.056
  Fibrin-alginate … 0 −2.5 13.0 −22.4 ± 18.0* 0.5 23.0c
a

p < 0.05 vs baseline.

b

p < 0.05 vs 7 days post-MI.

c

p < 0.05 vs. saline.

Values presented as mean ±standard error of the mean.

Saline: n = 9; Fibrin-alginate: n = 8.

LV = left ventricular; MI = myocardial infarction; NS = not significant.