Table 2.
Hemodynamic Variables at 28 Days After Myocardial Infarction: Effects of Saline or Fibrin-Alginate Injection at 7 Days After Myocardial Infarction
| Variable | Control | Saline | Fibrin-Alginate | p Valuea |
|---|---|---|---|---|
| LV peak pressure, mm Hg | 113 ± 2 | 110 ± 2 | 107 ± 2 | NS |
| LV end-diastolic pressure, mm Hg | 10 ± 1 | 10 ± 1 | 11 ± 1 | NS |
| Peak dP/dt, mm Hg/s | 1372 ± 121 | 1668 ± 212 | 1814 ± 161 | NS |
| Mean aortic pressure, mm Hg | 94 ± 1 | 93 ± 3 | 88 ± 4 | NS |
| Mean PA pressure, mm Hg | 22 ± 2 | 21 ± 1 | 26 ± 4 | NS |
| Cardiac index, mL/min/kg | 109 ± 4 | 87 ± 4b | 98 ± 5 | 0.007 |
| Wall stress in remote region, g/cm2 | 306.4 ± 17.2 | 306.4 ± 29.7 | 257.7 ± 22.9 | NS |
| Wall stress in MI region, g/cm2 | 277.8 ± 22.9 | 487.7 ± 54.6b | 431.7 ± 30.0b | 0.016 |
| Regional MI stiffness constant | 3.71 ± 0.57 | 10.38 ± 1.85b | 13.73 ± 2.08b | 0.006 |
| Sample size | 5 | 8 | 6 |
Calculated by analysis of variance.
p < 0.05 vs control.
Values presented as mean ± standard error of the mean.
LV = left ventricular; MI = myocardial infarction; NS = not significant; PA = pulmonary artery.