Table 2.
The HIF-1 binding sequences from 21 known HIF-1 target genes.
| Gene | Subsequences | Ref. | ||
|---|---|---|---|---|
| α1BAR | 5′-CAGGCGA | CGTG | CTGCCGGG-3′ | 23,24 |
| ADM | 5′-CCCGTGGCAAA | CGTG | TTC-3′ | 24 |
| 5′-GACAAA | CGTG | TCTAGCGTGAT-3′ | 24 | |
| 5′-ACAAA | CGTG | TCTAGCGTGAT-3′ | 25 | |
| ALDA | 5′-CCCCCTCGGA | CGTG | ACTCGGACCAC-3′ | 25 |
| 5′-GA | CGTG | ACT-3′ | 25 | |
| 5′-CTTCA | CGTG | CGGGGACCAGGGACCGT-3′ | 26 | |
| 5′-GGGATGTGGTCCGAGT | CACG | TCCG-3′ | 26 | |
| ET-1 | 5′-CGGGTCTTATCTCCGGCTG | CACG | TTGCCTGTGGGTGACTAAT CACACAATAA-3′ | 26 |
| ENO1 | 5′-GGCCA | CGTG | CGCCGCCTGCGCCTGCG-3′ | 26 |
| 5′-AGGGCCGGA | CGTG | GGGCCCC-3′ | 26 | |
| 5′-ACGCTGAGTG | CGTG | CGGGACTCGGAGTACGTGACGGA-3′ | 26 | |
| 5′-CGCA | CGTG | GCCCCGGACACGCAGC-3′ | 26 | |
| EPO | 3′-GCCCTA | CGTG | CTGTCTCACACAGCCTGTCTGAC-5′ | 26,27 |
| 3′-GCCCTA | CGTG | CTGTCTCACACAGCCTGTCTGAC CTACCGG-5′ | 28 | |
| 3′-GGGGCTGCTGCAGA | CGTG | CTGTCTCACACAGCCTGTCTGAC-5′ | 29 | |
| 3′-GCCCTA | CGTG | TCTCACACAGCCTGTCTGAC-5′ | 29 | |
| 5′-TGAGACAG | CACG | TAGGGC-3′ | 30 | |
| 5′-GCCCTA | CGTG | CTGCCTCGCAT-3′ | 26,27 | |
| 5′-GCTGGGCCCTA | CGTG | CTGTCTCACACAGCCTGTCT-3′ | 26,27 | |
| 5′-CCTA | CGTG | CTGTCTCACACAGCCT-3′ | 26,27 | |
| GLUT1 | 5′-TGGGTCCACAGG | CGTG | C-3′ | 31 |
| 5′-CAGG | CGTG | CCGTCTGACACGCATC-3′ | 32 | |
| HO-1 | 5′-GAGCGGA | CGTG | CTGGCGTGGCACGTCCTCTC-3′ | 33 |
| IGFBP1 | 3′-CAACTA | CGTG | CTCTGG-5′ | 34 |
| 5′-GCAGGA | CGTG | CTCTGGGGGGCACACATAGCT-3′ | 34 | |
| 3′-TGCCCA | CGTG | CTGGCA-5′ | 34 | |
| 3′-GACACA | CGTG | CTTTCT-5′ | 34 | |
| 3′-GACACA | CGTG | CTTCCT-5′ | 34 | |
| LDHA | 5′-ACA | CGTG | GGTTCCCGCACGTCCGC-3′ | 27 |
| 5′-GTGGGAGCCCAGCGGA | CGTG | CGGGAA-3′ | 27 | |
| 5′-CACA | CGTG | GGTTCCCGCACGTCCG-3′ | 26 | |
| iNOS | 5′-GTGACTA | CGTG | CTGCCTAGGGGCCACTGCC-3′ | 35 |
| 5′-AGTGACTA | CGTG | CTGCCTAGG-3′ | 28 | |
| p35srj | 5′-GTGTGCG | CGTG | GTGCCATACGGGACGT- GCAGCTACGTGCCCA-3′ | 30 |
| FKL | 5′-CCGGGTAGCTGGCGTA | CGTG | CTGCAG-3′ | 24 |
| PGK1 | 5′-GA | CGTG | ACAAACGAAGCCGCACGTC-3′ | 27 |
| 5′-CGCGT | CGTG | CAGGACGTGACAAATGGAAGTAG CACGTC-3′ | ||
| 5′-GTGAGA | CGTG | CGGCTTCCGTTTG-3′ | 24 | |
| 5′-CTGCCGA | CGTG | CGCTCCGGAG-3′ | 24 | |
| TF | 5′-TTCCTG | CACG | TACACACAAGCGCACGTATTTC-3′ | 36 |
| 5′-GTGTGATTGT | CGTG | GTAGTGGATTCCATGC-3′ | 36 | |
| 5′-A | CGTG | CGCTTTGTGTGTACGTGC-3′ | 36 | |
| TR | 5′-AGCGTA | CGTG | CCTC-3′ | 36 |
| 5′-CGCGAGCGTA | CGTG | CCTCAGG-3′ | 36 | |
| 5′-AGCGTA | CGTG | CCTCAGGAAGTGACG CACAGCCCCCCTG-3′ | 36 | |
| 5′-GGTGTA | CGTG | CGGAAGGAAGTGACGTAGATCCA GAGGG-3′ | 36 | |
| VEGF | 5′-CCACAGTGCATA | CGTG | GGCTCCAACAGGTCCTCTT-3′ | 27 |
| FLT-1 | 5′-TTGAGGAACAA | CGTG | GAATTAGTGTCATCGTAAAT-3′ | 37 |
| 5′-TTGAGGAACAA | CGTG | GAATTAGTGTCATAGCAAAT-3′ | 37 | |
| Met | 5′-TTAGCGGAGA | CGTG | GGAGAGGCCGAGAG CAAAGCTCGCG-3′ | 38 |
| 5′-ACCTTGT | CGTG | GGCGGGGCAGAGGCGGGAG GAAACGC-3′- | 38 | |
| 5′-CAGACA | CGTG | CTGGGGCGGGCAGG-3′ | 38 | |
| 5′-CAGCGCG | CGTG | TGGGAAGGGGCGGAGGGAGTGC-3′ | 38 | |
| 5′-GGAGCGCG | CGTG | TGGTCC-3′ | 38 | |
| Nip3 | 5′-CCCGCGCACGCGCCGCA | CGTG | CCGCACGCGCCCCGCG-3′ | 39 |
| RTP801 | 5′-ACGTTGCTTA | CGTG | CGCCCGG-3′ | 40 |
Abbreviations: α1BAR, α1B adrenergic receptor; ADM, adrenomedullin; ALDA, aldolase A; ET-1, endothelin-1; ENO1, enolase 1; EPO, erythropoietin; GLUT1, glucose transporter 1; HO-1, heme oxygenase 1; IGFBP1, insulin-like growth-factor binding protein 1; LDHA, lactate dehydrogenase A; iNOS, inducible nitric oxide synthase; PFKL, phosphofructokinase L; PGK1, phosphoglycerate kinase 1; PKM, pyruvate kinase M; TF, transferrin; TR, transferring receptor; VEGF, vascular endothelial growth factor; FLT-1, VEGF receptor. Note, in the above table, several sequences has “CACG” that is the complementary sequence of “CGTG”.