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Mecp2tm1.1Jae null mice exhibit a Rett-like respiratory phenotype at 5 weeks of age (P35). Representative plethysmographic recordings of quiet breathing from wildtype and Mecp2tm1.1Jae null mice. In contrast to the wildtype pattern of regular breathing, the null phenotype is extremely heterogeneous and includes significant periods of high breathing frequency, highly variable breath amplitudes and respiratory pauses. Modified from Ogier et al. (2007).
