Table 2.

Evolution of plasma glucose and insulin (fed state) in control rats and in ZDF rats receiving or not fenofibrate (F) or metformin (M).

Glucose mM	Control	ZDF	ZDF + F	ZDF + M
7 weeks	7.4 ± 0.3	7.3 ± 0.3	7.6 ± 0.2	7.4 ± 0.3
14 weeks	7.0 ± 0.4	30.1 ± 0.9***	31.5 ± 0.5***	31.6 ± 0.6***
21 weeks	7.6 ± 0.3	30.2 ± 0.2 ***	33.2 ± 0.2***	34.2 ± 0.4***
Insulin ng/l
7 weeks	4.7 ± 0.7	16.0 ± 3.0**	12.7 ± 0.8**	12.4 ± 1.1**
14 weeks	6.8 ± 1.1	4.3 ± 1.0	5.1 ± 0.7	6.3 ± 0.7
21 weeks	8.5 ± 0.5	<0.5 **	<0.5 **	<0.5 **

Results are shown are mean and sem. ** p < 0.01, *** p < 0.001 vs the corresponding control