Table 3.

Evolution of plasma TAG and NEFA (measured in the post-absorptive state) in control rats and in ZDF rats receiving or not fenofibrate (F) or metformin (M).

TAG mM	Control	ZDF	ZDF + F	ZDF + M
7 weeks	0.47 ± 0.04	4.12 ± 0.48 ***
14 weeks	0.50 ± 0.07	3.79 ± 0.40 ***	2.97 ± 0.77 **$	1.48 ± 0.42 *$$
21 weeks	0.54 ± 0.04	5.83 ± 1.01 ***	3.26 ± 0.40 ***$	2.40 ± 0.50 **$
NEFA μM
7 weeks	595 ± 71	491 ± 28
14 weeks	512 ± 59	1150 ± 95 **	985 ± 68 **	1052 ± 59 **
21 weeks	485 ± 63	1495 ± 152 ***	1310 ± 152 ***	1158 ± 125 ***

Results are shown are mean and sem. ** p < 0.01, *** p < 0.001 vs the corresponding control; $ p < 0.05, $$ p < 001 vs the corresponding ZDF group. These parameters were measured only in rats sacrificed for tissue sampling (n = 5 for each group), therefore they were measured at 7 weeks only in a group of 5 control and ZDF rats.