Table 4.

Evolution of plasma TAG and NEFA (measured in the fed state) in control rats and in ZDF rats receiving or not fenofibrate (F) or metformin (M).

TAG mM	Control	ZDF	ZDF + F	ZDF + M
7 weeks	0.89 ± 0.06	2.85 ± 0.39 ***	4.09 ± 0.44 ***	3.32 ± 0.29 ***
14 weeks	1.34 ± 0.08	10.40 ± 1.10 ***	6.50 ± 1.19 ***$	8.60 ± 1.07 ***
21 weeks	1.50 ± 0.12	9.86 ± 0.63 ***	12.10 ± 1.42 ***	13.20 ± 0.57 ***
NEFA μM
7 weeks	550 ± 62	435 ± 43	541 ± 64	523 ± 89
14 weeks	541 ± 64	1062 ± 103 ***	869 ± 107 ***	1098 ± 123 **
21 weeks	416 ± 27	824 ± 115 **	1121 ± 145 ***	1211 ± 104 ***

Results are shown are mean and sem** p < 0.01, *** p < 0.001 vs the corresponding control group; $ p < 0.05 vs the corresponding ZDF group.