Table 3.
Breast cancer risk associated with MPO polymorphism and dietary intakes
| Low consumption§ |
High consumption§ |
||||
|---|---|---|---|---|---|
| Cases/ Controls | OR (95% CI)a | Cases/ Controls | OR (95% CI)a | P for interaction¶ | |
| Fruit and vegetable* | |||||
| TT | 360/490 | 1.00 (Ref) | 330/492 | 0.89 (0.71, 1.11) | 0.26 |
| TC | 188/242 | 1.11 (0.87, 1.41) | 180/258 | 0.88 (0.68, 1.14) | |
| CC | 25/32 | 1.11 (0.63, 1.96) | 15/31 | 0.58 (0.30, 1.12) | |
| TT | 360/490 | 1.00 (Ref) | 330/492 | 0.89 (0.71, 1.11) | 0.37 |
| TC+CC | 213/274 | 1.11 (0.87, 1.40) | 195/289 | 0.84 (0.65, 1.08) | |
| Fruit* | |||||
| TT | 349/490 | 1.00 (Ref) | 341/492 | 0.98 (0.79, 1.22) | 0.86 |
| TC | 170/233 | 1.04 (0.81, 1.34) | 198/267 | 1.03 (0.80, 1.33) | |
| CC | 23/33 | 0.97 (0.54, 1.73) | 17/30 | 0.77 (0.41, 1.46) | |
| TT | 349/490 | 1.00 (Ref) | 341/492 | 0.98 (0.79, 1.22) | 0.98 |
| TC+CC | 193/266 | 1.03 (0.81, 1.31) | 215/297 | 1.01 (0.79, 1.29) | |
| Vegetable* | |||||
| TT | 372/499 | 1.00 (Ref) | 318/483 | 0.86 (0.69, 1.07) | 0.23 |
| TC | 206/236 | 1.18 (0.93, 1.51) | 162/264 | 0.78 (0.60, 1.01) | |
| CC | 24/35 | 0.92 (0.52, 1.61) | 16/28 | 0.70 (0.36, 1.35) | |
| TT | 372/499 | 1.00 (Ref) | 318/483 | 0.86 (0.69, 1.07) | 0.16 |
| TC+CC | 230/271 | 1.15 (0.91, 1.45) | 178/292 | 0.77 (0.60, 1.00) | |
| Carotenoids* | |||||
| TT | 386/534 | 1.00 (Ref) | 367/525 | 0.95 (0.78, 1.16) | 0.46 |
| TC | 211/260 | 1.12 (0.88, 1.42) | 192/282 | 0.96 (0.75, 1.22) | |
| CC | 24/37 | 0.94 (0.54, 1.62) | 18/33 | 0.68 (0.36, 1.27) | |
| TT | 386/534 | 1.00 (Ref) | 367/525 | 0.95 (0.77, 1.16) | 0.50 |
| TC+CC | 235/297 | 1.10 (0.87, 1.38) | 210/315 | 0.93 (0.73, 1.17) | |
| Vitamin C* | |||||
| TT | 374/523 | 1.00 (Ref) | 379/536 | 0.91 (0.74, 1.11) | 0.36 |
| TC | 182/270 | 0.92 (0.72, 1.17) | 221/272 | 1.11 (0.87, 1.40) | |
| CC | 22/33 | 0.93 (0.52, 1.67) | 20/37 | 0.67 (0.37, 1.22) | |
| TT | 374/523 | 1.00 (Ref) | 379/536 | 0.91 (0.74, 1.11) | 0.17 |
| TC+CC | 204/303 | 0.92 (0.73, 1.16) | 241/309 | 1.05 (0.84, 1.32) | |
| Vitamin E* | |||||
| TT | 381/529 | 1.00 (Ref) | 372/530 | 0.82 (0.67, 1.01) | 0.10 |
| TC | 203/281 | 0.94 (0.74, 1.20) | 200/261 | 0.99 (0.78, 1.26) | |
| CC | 19/38 | 0.67 (0.38, 1.21) | 23/32 | 0.85 (0.47, 1.53) | |
| TT | 381/529 | 1.00 (Ref) | 372/530 | 0.82 (0.67, 1.01) | 0.11 |
| TC+CC | 222/319 | 0.91 (0.72, 1.15) | 223/293 | 0.97 (0.77, 1.23) | |
Low and high consumption are based on median values of control group: fruit and vegetable, 5.43 servings/day; fruit, 2.18 servings/day; vegetable, 3.14 servings/day; carotenoids, 8962 IU/day; vitamin C, 227 mg/day; vitamin E, 15 mg/day.
ORs and 95% CIs are calculated by unconditional logistic regression adjusted for the matching factors and BMI at age 18, weight gain since age 18, age at menarche, personal history of benign breast disease, first-degree family history of breast cancer, age at first birth/parity, age at menopause, and duration of postmenopausal hormone use.
LRT comparing the nested models with interaction terms to the main effect models.
Numbers in the cells are smaller than the total sample size due to missing values in covariates.