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Insulin-mediated FoxO1 protein trafficking in HepG2 cells. (A) FoxO1 is localized to the nucleus (N) in the absence of insulin. (B) In response to insulin, FoxO1 is translocated to the cytoplasm (C). HepG2 cells pre-transfected with a plasmid encoding FoxO1-GFP fusion protein are exposed to insulin (100 nM) for 15 min, followed by immunofluorescent microscopy.
