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. Author manuscript; available in PMC: 2009 Apr 2.
Published in final edited form as: J Acquir Immune Defic Syndr. 2008 Jul 1;48(3):297–303. doi: 10.1097/QAI.0b013e31817bbc3a

TABLE 2.

Sensitivity, Specificity, PPV, NPV, and Area Under the Curve of Manual Bead Assays for CD4 Lymphocyte Count by Flow Cytometry of 497 Participants

Sensitivity (%) Specificity (%) PPV (%) NPV (%) AUC
Dynabeads (cells/mm3)
 <100 83 94 66 97 0.958
 <200 87 84 82 89 0.928
 <350 94 69 92 75 0.933
Cytospheres (cells/mm3)
 <100 73 87 41 96 0.879
 <200 93 59 64 91 0.886
 <350 99 32 85 84 0.905

Cut-points are 100, 200, or 350 cells/mm3 for both methods concurrently. AUC, area under the curve.