Table 3.
Microsatellite | Rate of mutation to 5-FOAR (per cell division) | Rate of changes in tract (per cell division)* | Types of alterations
|
||||
---|---|---|---|---|---|---|---|
−2 | 0 | +2 | Other† | Total | |||
(AT)16.5 | 5.1 (4.5–6.4) × 10−5 | 1.3 × 10−5 | 1 | 1 | 23 | 1 | 26 |
2.7 (2.6–3.1) × 10−5 | |||||||
3.9 × 10−5 | |||||||
(GT)16.5 | 4.0 (2.4–5.5) × 10−5 | 1.2 × 10−5 | 4 | 0 | 24 | 1 | 29 |
2.4 (1.9–3.3) × 10−5 | |||||||
3.2 × 10−5 |
These rates were determined by multiplying the average rate of mutation to 5-FOAR by the proportion of 5-FOAR derivatives that had altered tracts. Most of the 5-FOAR derivatives that did not have a tract alteration had lost the reporter gene as a consequence of mitotic recombination.
† In this class are two 5-FOAR strains in which the tract had gained more than five repeats.