Table 2.
Expression of claudin-1, -2, -3, -4, -5, and -7 in patients with UIP
| Localization | Claudin-1 | Claudin-2 | Claudin-3 | Claudin-4 | Claudin-5 | Claudin-7 |
|---|---|---|---|---|---|---|
| Alveolar epitheliuma | 0 (10) | 0 (10) | + (10) | + (10) | 0 (10) | + (10) |
| Bronchiolar epithelium | ++ (2) +++ (8) | ++ (3) +++ (7) | +++ (10) | +++ (10) | + (10) | +++ (10) |
| Metaplastic alveolar epitheliumb | ++ (2) +++ (8) | ++ (2) +++ (8) | ++ (5) +++ (5) | ++ (2) +++ (8) | + (10) | +++ (10) |
| Endothelium | (+)c (10) | 0 (10) | 0 (10) | 0 (10) | +++d (10) | 0 (10) |
a
Type II pneumocytes.
b
Metaplastic alveolar-type, metaplastic squamous-type, and metaplastic bronchiolar-type epithelium.
c
Very weak expression.
d
Very strong in remodeled arteries.
Total numbers of cases are shown in parentheses. UIP, usual interstitial pneumonia.