Table 3.

Expression and spatial localization of the ECM proteins in human bone^a

	Fibronectin			Laminin			Collagen I			Collagen IV
	BM	B	E	BM	B	E	BM	B	E	BM	B	E
Normal	++++	−	+++	+	−	+	++++	++++	+++	+	−	+
MGUS	++++	−	+++	+	−	+	++++	++++	+++	+++	−	++
MM (lowb)	++++	−	+++	+	−	+	++++	++++	+++	+++	−	++
MM (midc)	++	−	+++	+	−	+	+++	++++	+++	+++	−	++
MM (highd)	++	−	++	+	−	+	++	++++	++	++++	−	+++

^aScores were based on the expression of ECM proteins through the entire length of the core biopsy.

^bLow plasmacytosis (<20%).

^cMedium plasmacytosis (40–50%).

^dHigh plasmacytosis (>80%).

++++, very strong expression; +++, strong expression; ++, moderate expression; +, weak expression; −, negative.

ECM, extracellular matrix; BM, bone marrow; B, bone; E, endosteum; MGUS, monoclonal gammopathy of undetermined significance; MM, multiple myeloma.