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. 2009 Apr 10;4(4):e5161. doi: 10.1371/journal.pone.0005161

Table 2. Peak Location and LOD Score of Each QTL Depicted in Figure 1.

Name Trait Trait_Type Chr Peak (cM) Peak (Mb) LOD FDR* Period
Q1@39 Onset REM Fragmentation 1 38.470 109.044 4.445 .006 24 hour
Q1@39 db TS Fragmentation 1 39.120 115.677 3.453 .034 24 hour
Q1@39 db NREM Fragmentation 1 39.120 115.677 3.438 .034 24 hour
Q1@39 nb NREM Fragmentation 1 42.400 133.902 3.485 .026 24 hour
Q1@39 # Shifts Fragmentation 1 42.400 133.902 3.076 .033 24 hour
Q1@64 # Arousals Fragmentation 1 62.230 172.886 4.231 .004 24 hour
Q1@64 lat REM Latency 1 62.230 172.886 2.941 .046 24 hour
Q1@64 db Wake Fragmentation 1 62.230 172.886 3.991 .019 Dark
Q1@64 nb Wake Fragmentation 1 63.680 176.451 3.285 .018 Dark
Q1@64 REM rel Theta I Power Bands 1 63.680 176.451 2.790 .040 Mixed
Q1@75 lat NREM Latency 1 74.200 187.588 4.528 .001 24 hour
Q1@75 db TS Fragmentation 1 74.200 187.588 3.252 .023 Dark
Q1@75 lat NREM Latency 1 74.200 187.588 2.796 .019 Dark
Q1@75 NREM rel Delta Power Bands 1 74.200 187.588 3.097 .044 Mixed
Q1@75 Onset REM Fragmentation 1 74.580 188.870 3.475 .009 Dark
Q1@75 db NREM Fragmentation 1 76.960 189.312 3.176 .027 Dark
Q1@75 # Arousals Fragmentation 1 76.960 189.312 2.493 .041 Dark
Q3@12 NREM rel Delta Power Bands 3 12.180 30.690 2.745 .042 Mixed
Q3@71 lat NREM Latency 3 71.060 146.067 3.244 .027 24 hour
Q5@49 % REM/TS REM 5 45.290 65.322 4.225 .008 24 hour
Q5@49 db REM REM 5 49.320 70.388 6.339 .001 24 hour
Q5@49 REM REM 5 51.940 73.499 4.224 .005 24 hour
Q6@70 # Shifts Fragmentation 6 70.000 135.767 3.111 .040 24 hour
Q6@70 nb NREM Fragmentation 6 70.000 135.767 3.079 .033 24 hour
Q6@70 db Wake Fragmentation 6 70.000 135.767 3.666 .024 24 hour
Q7@1 db Wake Fragmentation 7 0.980 7.882 3.113 .045 24 hour
Q7@1 nb Wake Fragmentation 7 0.980 7.882 4.064 .012 24 hour
Q7@32 nb REM REM 7 31.770 50.217 4.288 .002 Mixed
Q7@40 REM min REM 7 40.200 67.412 3.608 .004 Light
Q7@63 Inter REM REM 7 59.900 102.969 4.014 .046 Mixed
Q7@63 Wake min State Length 7 62.850 114.066 4.812 .022 Mixed
Q7@63 NREM min State Length 7 65.140 114.924 4.443 .027 Light
Q9@15 lat NREM Latency 9 15.160 46.527 3.062 .026 24 hour
Q12@28 db TS Fragmentation 12 27.580 71.050 3.111 .035 24 hour
Q12@28 db NREM Fragmentation 12 27.580 71.050 3.119 .036 24 hour
Q13@2 # Arousals Fragmentation 13 0.000 4.692 2.536 .049 Light
Q13@2 lat REM Latency 13 1.640 14.548 2.829 .042 24 hour
Q13@2 Wake min State Length 13 1.970 16.724 5.139 .001 24 hour
Q13@2 NREM min State Length 13 1.970 16.724 3.593 .049 24 hour
Q13@23 db REM REM 13 20.030 60.142 3.299 .026 24 hour
Q13@23 REM min REM 13 22.660 68.690 6.302 <.001 24 hour
Q13@23 % REM/TS REM 13 22.660 68.690 6.473 <.001 24 hour
Q13@23 Inter REM REM 13 25.940 72.819 3.928 .012 24 hour
Q14@73 lat REM Latency 14 72.980 121.782 3.058 .046 24 hour
Q15@26 % REM/TS REM 15 26.300 82.415 4.040 .002 Dark
Q16@24 REM rel Theta I Power Bands 16 23.660 51.539 3.039 .037 Mixed
Q17@13 % REM/TS REM 17 3.940 24.849 4.263 .002 Mixed
Q17@13 db TS Fragmentation 17 13.120 44.789 2.601 .049 Mixed
Q17@29 nb REM REM 17 28.590 65.200 3.021 .014 Mixed
Q17@29 REM min REM 17 28.590 65.200 4.870 <.001 Mixed
Q17@29 Wake min State Length 17 30.230 65.622 7.562 <.001 Mixed
Q17@29 NREM min State Length 17 30.230 65.622 5.954 .001 Dark

QTL were detected by R package QTL as were the peak LOD scores. The QTL peak was defined as the position within the QTL with the highest LOD score. Trait type was determined by factor analysis (Table 1). Chr = chromosome, LOD = logarithm of odds. FDR = False Discovery Rate (probability). See Supplementary Information for complete trait descriptions. See Supporting Information Table S3 for further information about each QTL.

*

To account for multiple testing using a non-parametric approach, FDR estimates were computed genome-wide within each sleep trait by permuting individual identifiers for the genotype data and repeating the analyses on 1000 replicate permuted data sets [25]. To eliminate the influence of markers in high linkage disequilibrium, chromosome-wide peak marker LOD scores were used for all FDR computations.