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. Author manuscript; available in PMC: 2009 Apr 3.
Published in final edited form as: Mol Cell Neurosci. 2005 Sep;30(1):58–66. doi: 10.1016/j.mcn.2005.05.007

Fig. 2.

Fig. 2

Increase in neuronal p53 expression by gp120 requires CXCR4 activity. A specific CXCR4 antagonist, AMD3100 (100 ng/ml) completely abolishes the increase in p53 protein levels induced by gp120IIIB (200 pM, 3 h); this effect was observed with both total (A) and nuclear cell extracts (B) using monoclonal anti-p53. The graph (C) shows the analysis (mean ± SEM) of 3 experiments with total cell extracts (**P < 0.01 vs. gp120).