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. 2008 Jul 23;28(30):7513–7519. doi: 10.1523/JNEUROSCI.1951-08.2008

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Copyright © 2008 Society for Neuroscience 0270-6474/08/287513-07$15.00/0

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Figure 4. — Kv4.2 internalization requires PKA phosphorylation at Ser 552. A, Representative images show that AMPA (50 μm) does not induce redistribution of Kv4.2g^S552A from dendritic spines. AMPA treatment (n = 23 neurons, 1908 spines) had no effect on the percentage of spines containing Kv4.2g^S552A (92.17 ± 1.49%), compared with control (93.89 ± 0.87%; n = 25 neurons, 3247 spines; p = 0.33). B, FSK (10 μm; n = 6) significantly reduces the peak current density of I_A compared with untreated cultured neurons expressing Kv4.2g (Cont; n = 8; *p < 0.05). This effect was not observed in cultured neurons expressing Kv4.2^S552A (Cont, n = 6; FSK, n = 8; p = 0.65). All data are mean ± SE.