Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Topology of SERT derived from LeuT. The substrate-binding pocket is formed by residues positioned in TM1, TM3, TM6, and TM8 (shown in gray). Residues elucidated as critical in recognition of SSRIs and TCAs are indicated as follows: Tyr-95 (29), Asp-98 (23), Ala-169 (31), Ile-172 (28), Met-180 (30), Ser-276 (40), Phe-513 (30), Ser-545 (41), and Phe-586 (42).
