TABLE 1.

Impact of hSERT S438T on [³H]5HT uptake inhibition by SERT inhibitors

The K_i values for SERT inhibitors were determined at hSERT WT and hSERT S438T in a [³H]5HT uptake inhibition assay as described under “Experimental Procedures.” Data represent mean ± S.E. from at least six independent experiments (number of replicates are given in parentheses) each performed in triplicate. The number of methyl groups on the aminopropyl chain of the inhibitors is indicated.

** indicates p < 0.01.

*** indicates p < 0.001 (Student's t test).