Impact of hSERT S438T on [3H]5HT uptake inhibition by SERT
inhibitors
The Ki values for SERT inhibitors were determined at
hSERT WT and hSERT S438T in a [3H]5HT uptake inhibition assay as
described under “Experimental Procedures.” Data represent mean
± S.E. from at least six independent experiments (number of replicates
are given in parentheses) each performed in triplicate. The number of methyl
groups on the aminopropyl chain of the inhibitors is indicated.