TABLE 2.

Impact of hSERT S438T on [³H]MADAM competition binding by SERT inhibitors

The K_i values for SERT inhibitors were determined at hSERT WT and hSERT S438T in a [³H]MADAM competition binding assay as described under “Experimental Procedures.” Data represent mean ± S.E. from at least three independent experiments (number of replicates are given in parentheses) each performed in duplicate. The number of methyl groups on the aminopropyl chain of the inhibitors is indicated.

** indicates p < 0.01 (Student's t test).