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A model for the functional domains of FADD. The DED at the NH2 terminus binds to the DED of caspase 8 and cFLIP. The DD of FADD interacts with the DD of Fas and TRADD, which is blocked by the R117Q mutation. The sequence in the proximity of Arg-117 and V121N may represent an interface contacting a novel protein (X?), which is critical for mouse development. The phosphorylated Ser-191 is indicated.
