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Model to explain SecA2 function and the phenotypes of Walker Box secA2 alleles. SecA2 exports select proteins across the cytoplasmic membrane through a mechanism involving SecA1 and a membrane-embedded translocase. Amino acid substitution in the ATP-binding site of SecA2, as in SecA2 K129R, results in a dominant negative SecA2 protein trapped at the translocase and compromising an essential process.
