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Reactions catalyzed by KshAB in the cholesterol catabolic pathway. Cholesterol is transformed to AD via previous enzymatic steps. KshA catalyzes the 9α-hydroxylation of AD and ADD, yielding 9-OHAD and 9-OHADD, respectively. KstD catalyzes the desaturation of ring A of AD and 9-OHAD to form ADD and 9-OHADD, respectively; the physiological electron acceptor of KstD has yet to be identified. 9-OHADD undergoes a nonenzymatic ring cleavage and aromatization to form HSA.
