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. Author manuscript; available in PMC: 2009 Apr 3.
Published in final edited form as: Hear Res. 2007 Jun 27;232(1-2):1–19. doi: 10.1016/j.heares.2007.06.011

Figure 7.

Figure 7

(A) After incubation in ACM alone for 24 hours, cellular extrusions are not observed above the sensory epithelium in sections of explants embedded in methacrylate. (B) In sections from explants fixed 18 hours after a 6-hour incubation with gentamicin, cellular extrusions (*) are frequently seen above the sensory epithelium. Sections from explants co-incubated with gentamicin plus colchicine (C), taxol (D), ML-9 (E) or Y-27632 (F) also frequently had extrusions (*) above the sensory epithelium. Sections from explants treated with gentamicin plus latrunculin A (G) or cytochalasin D (H) did not display cellular extrusions, and had numerous translucent hair cell bodies (arrowheads) embedded within the sensory epithelium. In addition, explants treated with gentamicin plus cytochalasin D, fine protrusions of cellular material (small arrows) can be seen extending from supporting cells into the extracellular space above. Scale bar in microns.