Table 3.

Factors influencing the time to undectability (HBV-DNA < 200 copies/mL), univariate analysis

	Crude Hazard Ratio	CI 95%	p
TDF v. ADV	2.22	(0.99–4.94)	0.05
HBV load at baseline
- per log₁₀ copies/mL HBV-DNA	0.66	(0.55–0.80)	<0.001
- < 2000 copies/mL	1.00	**	**
- 2000 – 10,000 copies/mL	0.12	(0.03–0.46)	0.002
- > 10,000 copies/mL	0.05	(0.02–0.14)	<0.001
Presence of HBe antigen in serum	0.13	(0.04–0.41)	<0.001
Presence of YMDD mutation	0.77	(0.29–2.07)	0.6
Presence of Pre C mutation	0.60	(0.28–1.28)	0.2
HIV load at baseline (per log₁₀ HIV-RNA)	0.85	(0.47–1.54)	0.6
Duration of HIV infection (per year)	0.95	(0.88–1.02)	0.14
CD4+ Cell Count (≥ 402/mm³)	0.74	(0.42–1.31)	0.3
METAVIR Fibrosis F0–F2 vs F3–F4	1.72	(0.78–3.79)	0.2
ALT level at baseline (≥72 UI/mL = median)	0.46	(0.25–0.85)	0.01
Additional HCV co-infection	1.42	(0.44–4.58)	0.6
Alcohol consumption (cut at the median)	0.71	(0.40–1.29)	0.3