Table 1.
Subject characteristics, clinical ratings, and neuropsychological test scores
| Characteristic, rating, or test score | Noncarriers (n = 12) | Heterozygotes (n = 8) | Homozygotes (n = 8) | P value |
|---|---|---|---|---|
| Age, years | 64 ± 5 (57–71) | 67 ± 4 (60–72) | 63 ± 4 (60–71) | .14 |
| Females/males | 9 / 3 | 7 / 1 | 5 / 3 | .51 |
| Educational level, years | 15 ± 2 | 17 ± 2 | 15 ± 2 | .02 |
| MMSE score | 29.7 ± 0.7 (28–30) | 29.6 ± 1.1 (27–30) | 29.6 ± 0.7 (28–30) | .99 |
| Auditory verbal learning test scores | ||||
| Total learning | 48.1 ± 6.2 | 50.9 ± 11.2 | 47.4 ± 11.8 | .74 |
| Short-term recall | 9.1 ± 2.7 | 10.0 ± 3.5 | 9.4 ± 4.2 | .84 |
| Long-term recall | 8.5 ± 3.3 | 10.6 ± 3.8 | 8.5 ± 4.0 | .40 |
| Complex figure test scores | ||||
| Copy | 34.5 ± 2.0 | 32.5 ± 3.9 | 35.4 ± 0.9 | .08 |
| Recall | 19.4 ± 7.3 | 21.2 ± 9.3 | 19.8 ± 6.5 | .88 |
| Boston naming test | 56.4 ± 2.9 | 56.6 ± 4.0 | 57.0 ± 2.5 | .92 |
| Wechsler Adult Intelligence Scale-Revised scores | ||||
| Information | 14.3 ± 7.1 | 13.3 ± 3.0 | 12.3 ± 1.8 | .69 |
| Digit span | 11.3 ± 2.4 | 12.8 ± 3.5 | 12.0 ± 2.3 | .53 |
| Block design | 12.6 ± 2.7 | 12.4 ± 2.9 | 13.0 ± 3.1 | .91 |
| Mental arithmetic | 11.8 ± 2.2 | 12.1 ± 3.4 | 13.3 ± 2.5 | .51 |
| Similarities | 11.8 ± 1.5 | 13.3 ± 3.2 | 13.5 ± 1.6 | .18 |
| Controlled oral word association test | 47.5 ± 11.8 | 53.6 ± 10.6 | 49.8 ± 2.5 | .40 |
| Wechsler Memory Scale-Revised Orientation subtest score | 14.0 ± 0.0 | 13.9 ± 0.4 | 13.8 ± 0.5 | .22 |
Values are means ± SD with ranges in parentheses as appropriate. P values were calculated using the unpaired 2-tailed t-tests or 2-tailed Pearson χ2 test, uncorrected for multiple comparisons.