Table 2.

Location and magnitude of maximally significant relationships between fibrillar Aβ burden and APOE ε4 gene dose

		Heterozygotes > noncarriers					Homozygotes > noncarriers					APOE ε4 gene dose
		Atlas coordinates			z- score	P value	Atlas coordinates			z- score	P value	Atlas coordinates			z- score	P value
		X	Y	Z			X	Y	Z			X	Y	Z
Anterior cingulate/frontal	L	−8	26	13	4.1	4e-4	−6	29	2	4.7	2e-5*	−4	26	13	5.6	4e-6*
	R	36	46	27	3.8	7e-4	32	56	−10	4.7	2e-5*	6	27	6	5.2	1e-5*
Mid-cingulate/posterior cingulate/precuneus	L	−4	−53	25	3.5	1e-3	−2	−58	36	4.1	1e-4*	−2	−14	30	4.4	9e-5*
	R	14	0	30	3.7	9e-4	2	19	29	4.0	1e-4*	2	19	29	4.2	1e-4*
Lateral temporal	L						−44	−44	−21	3.6	5e-4*	−46	−46	−21	3.7	5e-4*
	R	59	7	−17	3.5	1e-3	55	−13	−26	5.0	8e-6*	57	−9	−30	6.0	1e-6*
Basal ganglia	L	−6	−17	8	4.7	1e-4*	−2	−19	8	3.6	5e-4*	−10	12	30	5.3	9e-6*
	R						20	−2	−7	4.1	1e-4*	10	19	−8	4.4	8e-5*
Medial temporal	L						−12	−2	−10	3.6	5e-4*	−10	−6	−10	5.0	2e-5*
	R						22	−2	−10	4.2	1e-4*	20	−6	−10	4.2	1e-4*
Lateral parietal/parietotemporal	L						−55	−37	31	3.0	3e-3*	−57	−15	15	3.7	5e-4*
	R	57	−27	42	3.8	7e-4	48	−26	23	3.7	3e-4*	46	−24	23	4.0	2e-4*
Occipital/occipitotemporal	L						−42	−68	29	3.1	2e-3
	R						44	−25	−26	4.4	5e-5*	32	−10	37	4.5	7e-5*

The data were extracted from voxels associated with maximally significant cerebral-to-cerebellar PiB DVR increases in the cognitively normal APOE ε4 homozygote versus noncarrier and heterozygote versus noncarrier comparisons (using the 2-tailed t-test) and in association with APOE ε4 gene dose (using 2-tailed linear trends). Listed locations correspond to the brain maps shown in Fig. 2 A–C and correspond to P ≤ .005, uncorrected for multiple comparisons. Asterisks denote locations that remain significant after correction for multiple comparisons (familywise error), based on random field theory within the ROI. Atlas coordinates were obtained from Talairach and Tournoux (41). X is the distance to the right (+) or left (−) of the midline, Y is the distance anterior (+) or posterior (−) to the anterior commissure, and Z is the distance superior (+) or inferior (−) to a horizontal plane through the anterior and posterior commissures.