Table 2.
mtDNA copy number in polg-1(ok1548); glp-4(bn2) mutant
| Developmental stages | 25°C |
15°C |
||||||
|---|---|---|---|---|---|---|---|---|
| N2 (wild type) ×104 | polg-1(ok1548) ×104 | glp-4(bn2) ×104 | polg-1(ok1548); glp-4(bn2) ×104 | N2 (wild type) ×104 | polg-1(ok1548) ×104 | glp-4(bn2) ×104 | polg-1(ok1548); glp-4(bn2) ×104 | |
| L3 (n = 3) | 31.28 ± 0.12 | 22.42 ± 2.35 | 24.28 ± 3.49 | 17.40 ± 2.29 | 69.99 ± 8.12 | 51.47 ± 3.46 | 64.18 ± 5.37 | 45.91 ± 0.81 |
| L4 (n = 3) | 191.19 ± 13.97 | 22.74 ± 0.45 | 28.45 ± 9.30 | 17.62 ± 1.48 | 192.09 ± 2.45 | 62.78 ± 2.28 | 108.41 ± 18.26 | 53.24 ± 4.16 |
| D1 (n = 3) | 388.70 ± 67.09 | 16.59 ± 2.60 | 37.56 ± 5.89 | 12.54 ± 1.82 | 499.38 ± 59.41 | 62.44 ± 0.27 | 289.82 ± 48.83 | 56.13 ± 6.17 |
| D4 (n = 3) | 692.05 ± 65.80 | 14.24 ± 1.12 | 43.20 ± 8.43 | 9.91 ± 1.98 | 849.49 ± 129.12 | 52.62 ± 1.12 | 745.62 ± 87.33 | 50.49 ± 2.36 |
Numbers represent absolute mtDNA levels/worm ± SEM. Level of statistical significance (**P<0.01, ***P<0.001, Student's t-test). D1 and D4 refers to a day 1 and day 4 of adulthood, respectively.