Table 4.
Statistical analysis of adult lifespan
| Genotype | Mean ± SEM | Maxa (days) | Number of animals that died/totalb |
|---|---|---|---|
| polg-1(ok1528) | 10 ± 3 | 15.3 | 313/365*** |
| wild type (N2) | 19 ± 7 | 30.2 | 334/370 |
| DR2078 | 22 ± 8 | 32.1 | 152/165*** |
| polg-1(ok1548/+) | 19 ± 6 | 28.5 | 119/165 |
| polg-1(ok1528),HIS72::mCherry | 17 ± 4 | 23.4 | 195/204***/c*** |
| HIS-72::mCherry | 21 ± 4 | 29.9 | 162/200 |
| wild type (N2)d | 9 ± 2 | 14.2 | 201/223 g*** |
| polg-1(ok1548)d | 8 ± 2 | 12 | 190/200 g*** |
| polg-1(ok1548), glp-4(bn2)d | 8 ± 3 | 15.4 | 186/200 g***/e* |
| glp-4(bn2)d | 10 ± 4 | 18.1 | 196/200 |
aMaximum lifespan shown is a median lifespan of the longest lived 10% of the animals assayed.
bThe total number of events equals the number of animals that died plus the number censored. For comparing significant distributions, statistical analysis of data was performed with the log-rank (Mantel–Cox) test. P-values were calculated for individual experiments consisting of control and experimental animals examined at the same time.
dAnimals were grown on 25°C. Comparisons are done either with wild type, (c) with HIS-72::mCherry animals, (g) with glp-4(bn2) and (e) with polg-1(ok1548) animals (*P<0.05, ***P<0.0001).