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. 2009 Feb 10;37(6):1984–1990. doi: 10.1093/nar/gkp033

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — The p53 consensus sequence. The purine (R) and pyrimidine (Y) bases comprise the flanking sequence. C(A/T)(A/T)G is the core sequence, and the (A/T)(A/T) within the core sequence is an A/T gap. The whole site is 20 bases with a ten-base direct repeat as a 2× half site, and each 10 bases are a 1× half site. Each five bases are quarter sites. A whole site with a core sequence C to G mutation within the first quarter site is a 1.5× half site, with a core sequence G to C mutation within the fourth quarter site is another 1.5× half site.