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. 2009 Feb 10;37(6):1984–1990. doi: 10.1093/nar/gkp033

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — The promoter activity in various A/T gap core sequences of p53 promoter response element. (A) Designed various A/T gap core sequence p53 response elements. m4-1g CAG: fourth quarter-site mutation and first half-site core sequence CAG. m4-2g CATG, m4-3g CATAG, m4-4g CATTAG, m4-4g CATATG, m4-5g CATATAG and d12 as negative control as in Figure 2B. (B) Designed various A/T gap core sequences of p53 promoter response element constructs were cotransfected with p53 expression vector into H1299 cells, and the luciferase promoter activity was compared to pcDNA3.0 as 1. The activity order is: m4-2g CATG > m4-4g CATATG > m4-4g CATTAG. No activity could be detected in m4-1g CAG, m4-3g CATAG, m4-5g CATATAG or d12.