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. Author manuscript; available in PMC: 2009 Apr 4.
Published in final edited form as: Nat Rev Immunol. 2008 Jul;8(7):523–532. doi: 10.1038/nri2343

Figure 2. Model for how effector T cells might boost Treg-cell function.

Figure 2

This occurs in three stages. (a) Initial regulatory T (Treg)-cell activation induces production of regulatory factors such as interleukin-35 (IL-35). (b) Treg cells ‘sense’ the presence of recently activated effector T cells through a receptor–ligand interaction (cell surface or soluble). (c) This in turn boosts or potentiates Treg-cell function resulting in the enhanced production of regulatory mediators, such as IL-35, and perhaps the induction of new mediators.