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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2008 Dec;67(12):1166–1186. doi: 10.1097/NEN.0b013e318190d6db

Figure 11.

Figure 11

Accumulation of autophagosomes in diabetic presynaptic dystrophic axon terminals. (A, B) Presynaptic nerve terminal contents range from single multivesicular bodies (MVBs) (arrow, A) to large forms with numerous MVBs admixed with mitochondria (B). Magnification bars: A, 500 nm; B, 500 nm. (C, D) MVBs consist of collections of synaptic vesicles (arrow, C), common in early dystrophic lesions, to tubulovesicular elements in later dystrophic terminals (arrows, D). Magnification bars: C, 500 nm; D, 500 nm.