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. Author manuscript; available in PMC: 2009 Dec 1.

Published in final edited form as: J Neuropathol Exp Neurol. 2008 Dec;67(12):1166–1186. doi: 10.1097/NEN.0b013e318190d6db

(A) The neuropil of this diabetic mouse ganglion contains both markedly enlarged neurites as well as numerous lucent small dendritic processes (arrows). Magnification bar: 10 μm. (B) An enlarged neurite within a satellite cell sheath results in the distortion of the contours of the adjacent neuronal cell body. Magnification bar: 2 μm. (C, D) A markedly dilated tubulovesicular-laden process shows a maintained presynaptic axon at its lower margin (arrow, C) seen at higher magnification in D. Magnification bars: C, 2 μm; D, 500 nm. (E) A small dendrite with a maintained synapse shows accumulated lucent tubulovesicular processes. Magnification bar: 500 nm. (F–H) The accumulated tubulovesicular elements are heterogeneous with lucent tubules and vesicles interspersed with cytoplasm (F), complex collections of coated vesicles forming unusual shapes (arrow, G), others part of multivesicular bodies (arrowhead, G), or delicate anastomosing tubulovesicular elements with proteinaceous intraluminal content (arrow, H). Magnification bars: F, 500 nm; G, 100 nm; H, 500 nm. (I, J) Occasional tubulovesicular elements appear to arise from the plasmalemma with partial clathrin coats (arrow, I) or contain residual ribosomes that may derive from rough endoplasmic reticulum (arrows, J). Magnification bars: I, 100 nm; J, 500 nm.

(A) The neuropil of this diabetic mouse ganglion contains both markedly enlarged neurites as well as numerous lucent small dendritic processes (arrows). Magnification bar: 10 μm. (B) An enlarged neurite within a satellite cell sheath results in the distortion of the contours of the adjacent neuronal cell body. Magnification bar: 2 μm. (C, D) A markedly dilated tubulovesicular-laden process shows a maintained presynaptic axon at its lower margin (arrow, C) seen at higher magnification in D. Magnification bars: C, 2 μm; D, 500 nm. (E) A small dendrite with a maintained synapse shows accumulated lucent tubulovesicular processes. Magnification bar: 500 nm. (F–H) The accumulated tubulovesicular elements are heterogeneous with lucent tubules and vesicles interspersed with cytoplasm (F), complex collections of coated vesicles forming unusual shapes (arrow, G), others part of multivesicular bodies (arrowhead, G), or delicate anastomosing tubulovesicular elements with proteinaceous intraluminal content (arrow, H). Magnification bars: F, 500 nm; G, 100 nm; H, 500 nm. (I, J) Occasional tubulovesicular elements appear to arise from the plasmalemma with partial clathrin coats (arrow, I) or contain residual ribosomes that may derive from rough endoplasmic reticulum (arrows, J). Magnification bars: I, 100 nm; J, 500 nm.