Table 3.

Effect of Diabetes on Mean Presynaptic Axon Terminal Cross Sectional Area of Sympathetic Ganglia

Experimental Group	Age	Diabetes (duration)	Synapses (#)	Presynaptic Axon Terminal Cross Sectional Area (square microns)
NOD Mice
SMG-CGs
Control (n = 6)	6 months		74 ± 12	0.75 ± 0.06
Diabetics (n = 5)	6 months	3–5 weeks	92 ± 4	1.33 ± 0.14*
SCG
Controls (n = 3)	6 months		60 ± 6	0.97 ± 0.02
Diabetics (n = 3)	6 months	3–5 weeks	48 ± 10	0.82 ± 0.03#
B6D2F1 + STZ Exp
Controls (n = 3)	6.5 months		111 ± 18	0.75 ± 0.05
Diabetics (n = 4)	6.5 months	5 months	97 ± 12	1.28 ± 0.08*
C57BL6 + STZ
Controls (n = 3)	4–6 months		83 ± 16	0.76 ± 0.04
Diabetics (n = 5)	4–6 months	3–4 months	59 ± 3	1.15 ± 0.06*
NOD-SCID + STZ
Controls (n=4)	3 mo		75 ± 10	0.91 ± .04
Diabetics (n=5)	3 mo	2–4 weeks	88 ± 7	1.28 ± 0.04*

Values represent the means ± SEM of the mean cross-sectional area of 50 to 125 synapses sampled from each of n mice. Statistical comparison:

^*p ≤ 0.01;

^#p ≤ 0.05.