Table IV.
Plasma cytokine concentrations in Duffy KO and WT mice following LPS stimulation of whole blood in vitroa
Duffy Ag Genotype |
|||
---|---|---|---|
Cytokine | KO | WT | p |
MIP-2 | 3728 ± 1605 | 495 ± 270 | 0.03 |
KC | 2654 ± 578 | 1691 ± 346 | 0.39 |
TNF-α | 132 ± 37 | 68 ± 42 | 0.12 |
CCL2 | OOR< | OOR< | NA |
MIP-2, KC, TNF-α, and CCL2 concentrations in picograms per milliliter and their corresponding SEM are depicted in columns according to genotype. OOR<, Out of range and below the sensitivity of the assay. NA, Not available. Statistical comparisons made between genotypes for each variable cytokine are depicted in the far right-hand column. Data were analyzed by rank sum Mann-Whitney U test and p ≤ 0.05 defined as significant. Data reflects n = 4–6 animals per group and are representative of two independent experiments.