Fig. 2.
Expression and role of CCL18 under physiological and immunopathological conditions. CCL18 is mainly expressed by monocytes/macrophages (Mono/Mϕ) and immature DC (Imm DC), whether or not after additional activation/maturation (marked by thin, straight arrows). The released CCL18 protein can attract lymphocytes and immature DC (depicted by thick, straight arrows) and induce collagen deposition by fibroblasts (curved arrow). In this way, CCL18 can contribute to various normal and immunopathological processes.