Table 1. Homologous genes on the human X and Y chromosomes.
| Region | Distance from Xpter (Mb) | X gene* | Y gene | Distance from Ypter (Mb)† | XY homology block‡ |
|---|---|---|---|---|---|
| Pseudoautosomal region PAR1 (XAR) | 0.15 | cU136G2.1 (PLCXD1) | cU136G2.1 (PLCXD1) | 0.15 | PAR1 |
| 0.17 | cU136G2.2 (GTPBP6) | cU136G2.2 (GTPBP6) | 0.17 | PAR1 | |
| 0.25 | cM56G10.2§ | cM56G10.2§ | 0.25 | PAR1 | |
| 0.29 | cM56G10.1 (PPP2R3B) | cM56G10.1 (PPP2R3B) | 0.29 | PAR1 | |
| 0.57 | SHOX | SHOX | 0.57 | PAR1 | |
| 0.92 | bA309M23.1§ | bA309M23.1§ | 0.92 | PAR1 | |
| 1.31 | CRLF2 | CRLF2 | 1.31 | PAR1 | |
| 1.38 | CSF2RA | CSF2RA | 1.38 | PAR1 | |
| 1.52 | IL3RA | IL3RA | 1.52 | PAR1 | |
| 1.55 | SLC25A6 | SLC25A6 | 1.55 | PAR1 | |
| 1.56 | bA261P4.5§ | bA261P4.5§ | 1.56 | PAR1 | |
| 1.57 | bA261P4.6 (CXYorf2) | bA261P4.6 (CXYorf2) | 1.57 | PAR1 | |
| 1.59 | ASMTL | ASMTL | 1.59 | PAR1 | |
| 1.66 | bA261P4.4 (P2RY8) | bA261P4.4 (P2RY8) | 1.66 | PAR1 | |
| 1.76 | DXYS155E (CXYorf3) | DXYS155E (CXYorf3) | 1.76 | PAR1 | |
| 1.79 | ASMT | ASMT | 1.79 | PAR1 | |
| 1.79 | bB297E16.3§ | bB297E16.3§ | 1.79 | PAR1 | |
| 1.91 | bB297E16.4§ | bB297E16.4§ | 1.91 | PAR1 | |
| 1.93 | bB297E16.5§ | bB297E16.5§ | 1.93 | PAR1 | |
| 2.37 | DHRSX | DHRSX | 2.37 | PAR1 | |
| 2.41 | ALTE (ZBED1) | ALTE (ZBED1) | 2.41 | PAR1 | |
| 2.54 | Em:AC097314.2§ | Em:AC097314.2§ | 2.54 | PAR1 | |
| 2.53 | Em:AC097314.3§ | Em:AC097314.3§ | 2.53 | PAR1 | |
| 2.63 | CD99 | CD99 | 2.63 | PAR1 | |
| X-added region (XAR) | 3.57 | PRKX | PRKY | 7.23 | 2 |
| 5.81 | NLGN4X | NLGN4Y | 15.23 | 5 | |
| 6.31 | Em:AC108684.1 (VCX3A) | VCY, VCY1B | 14.54, 14.6 | 6 | |
| 7.62 | VCX | VCY, VCY1B | 14.54, 14.6 | 9 | |
| 7.95 | Em:AC097626.1 (VCX2) | VCY, VCY1B | 14.54, 14.6 | 10 | |
| 8.24 | Em:AC006062.2 (VCX3B) | VCY, VCY1B | 14.54, 14.6 | 10 | |
| 9.37 | TBL1X | TBL1Y | 6.97 | 11 | |
| 11.07 | AMELX | AMELY | 6.78 | 12 | |
| 12.75 | TMSB4X | TMSB4Y | 14.25 | ||
| 16.59 | CXorf15 | CYorf15A, CYorf15B | 20.13, 20.15 | ||
| 19.91 | EIF1AX | EIF1AY | 21.08 | ||
| 23.96 | ZFX | ZFY | 2.87 | ||
| 40.78 | USP9X | USP9Y | 13.33 | ||
| 40.96 | DDX3X | DDX3Y | 13.46 | ||
| 44.61 | UTX | UTY | 13.91 | ||
| X-conserved region (XCR) | 53.00 | dJ290F12.2 (TSPYL2) | TSPY (~35) | 9.50 | |
| 53.12 | SMCX | SMCY | 20.27 | ||
| 71.27 | RPS4X | RPS4Y1, RPS4Y2 | 2.77, 21.27 | ||
| X-transposed region (XTR) | 88.50 | bB348B13.2§ | n/a | 2.96 | XTR |
| 88.99 | TGIF2LX | TGIF2LY | 3.49 | XTR | |
| 91.26 | PCDH11X | PCDH11Y | 5.28 | XTR | |
| X-conserved region (XCR) | 135.68 | RNMX (RBMX) | RBMY (6) | 22.02, 22.04, 22.37, 22.41, 22.66, 22.85 | |
| 139.31 | SOX3 | SRY | 2.70 | ||
| 148.38 | Em:AC016940.3 (HSFX2)§ | HSFY1, HSFY2 | 19.3, 19.12 | ||
| 148.56 | Em:AC016939.4 (HSFX1)§ | HSFY1, HSFY2 | 19.3, 19.12 | ||
| Pseudoautosomal region PAR2 | 154.57 | SPRY3 | SPRY3 | 57.44 | PAR2 |
| 154.71 | SYBL1 | SYBL1 | 57.58 | PAR2 | |
| 154.81 | IL9R | IL9R | 57.67 | PAR2 | |
| 154.81 | Em:AJ271736.5§ | Em:AJ271736.5§ | 57.69 | PAR2 | |
| 154.82 | Em:AJ271736.6 (FAM39A)§ | Em:AJ271736.6 (FAM39A)§ | 57.69 | PAR2 |
Pseudogenes are not included in the table.
*
Gene names as shown in Supplementary Fig. 1. HUGO name is in parentheses when the two names differ. Em, EMBL entry.
†
Distances refer to Y chromosome sequence assembly NCBI35. Where multiple Y chromosome orthologues exist, the locations of all copies are shown on the Y chromosome. The exception is TSPY, which has ~35 copies in an array centred at approximately 9.5 Mb on the Y chromosome41.
§
Novel cases of X genes with Y homologues assigned to these categories.