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. Author manuscript; available in PMC: 2009 Apr 6.
Published in final edited form as: Mol Biol Evol. 2006 Oct 11;24(1):203–216. doi: 10.1093/molbev/msl145

Figure 1. Delineation and structure of the human Rho family.

Figure 1

Proteins considered so far as Rho members were aligned with GTPases of other Ras-like families and the unrooted tree was obtained by NJ (ClustalX). Bootstrap values at critical nodes show that MIRO proteins constitute a distinct Ras-like family and RhoBTB3 is branched outside the Rho family. Identical topology was obtained using maximum likelihood (ProML3.6.3). Only the Rho domains, corresponding to aminoacids 5-173 of Rac1, were used for the alignment. Structuration into 4 clusters and 8 sub-families is figured by light and dark grey ellipses respectively. When different, common names are figured into brackets under the HUGO nomenclature.