Figure 3.

The anti-diabetogenic effect of anti-CD44 mAb. Male NOD mice were injected with IM7.8.1 anti-CD44 mAb, isotype-matched control mAb (4D2), IRAWB14.4 anti-CD44 mAb, or PBS, 1 hr before splenocyte transfer from diabetic NOD female mice. The mice were then injected with the same reagents on alternate days for the next 4 weeks, as described in the experimental protocol. Development of diabetes was monitored by glucosuria determination. The data pooled from 10 similar experiments are shown. The Breslow statistical analysis (p) was used to compare the PBS group with all of the other groups. NS, not significant.