Figure 4.

Inhibition of prediabetes onset by anti-CD44 mAb. Recipient NOD female mice with onset of active prediabetes, as determined by IPGTT 4 to 7 weeks after cell transfer, were randomly assigned to two groups. One group was injected with IM7.8.1 anti-CD44 mAb, and the other with isotype-matched control mAb (4D2) on alternate days for 4 weeks. Development of diabetes was monitored by glucosuria determination. Data were pooled from two similar experiments. The Breslow statistical analysis (p) was used to compare the 4D2 group with the IM7 group. Note that the IPGTT positive prediabetic mice were still glucosuria negative at the beginning of the experiment. Therefore, they were categorized as “diabetes-free mice.”