Fig. 1.

Immunostaining of REG Iα, Ki67 and single-strand DNA (ssDNA) in minor salivary gland (MSG) tissues. REG Iα expression is (a) negative in any types of cell in normal MSG but (b) positive in the ductal epithelial cells in inflamed MSG from Sjögren's syndrome (SS) patients. (c) Ki67 immunoreactivity is scattered in the normal MSG. (d) Ki67 immunoreactivity is observed in a considerable number of inflammatory cells and REG Iα-positive ductal cells in inflamed MSG from SS patients. (e) Hardly any signal for ssDNA in the ductal cells of the normal MSG. (f) Considerable signal for ssDNA in the ductal cells of SS patients.