Fig. 4.

The effects of rapamycin (RAPA) on human immunodeficiency virus (HIV) RNA blood levels in HIV-infected human peripheral blood leucocytes (hu-PBL)-SCID mice. Plasma samples were collected 3 weeks after viral infection to measure HIV-1 RNA copy numbers. HIV-1 proviral DNA was detected by specific amplification of HIV-1 gag sequences in samples collected from mice receiving RAPA treatment (0·6 versus 6 mg/kg) or vehicle treatment alone as a control. *P = 0·028 versus the vehicle-treated samples. Each group consisted of eight mice.