Table 2.
Activation markers and cytokine levels in 15 human immunodeficiency virus (HIV)-infected patients after 1 year of highly active anti-retroviral therapy and in 10 controls.
| Activation markers | Patients, % | Controls, % | P |
|---|---|---|---|
| CD4+CD25+ cells | 4·4 (3·4; 10) | 4·8 (3·1; 6·6) | 0·96 |
| CD4+CD69+ cells | 4·8 (3·2; 10) | 4·2 (4·2; 8·5) | 0·98 |
| CD4+CD38+HLA-DR+ cells | 3·4 (2·4; 9·7) | 3·1 (2·7; 5·4) | 0·31 |
| CD8+CD25+ cells | 0·4 (0·02; 1·1) | 1·3 (0·5; 2·1) | 0·96 |
| CD8+CD69+ cells | 3·4 (2·3; 5·7) | 5·7 (3·3; 6·8) | 0·24 |
| CD8+CD38+HLA-DR+ cells | 5·5 (3; 6·4) | 3·1 (1·9; 4) | 0·21 |
| Cytokine | Patients, MFI | Controls, MFI | P |
| IFN-γ | 116 (92; 192) | 148 (95; 181) | 0·64 |
| IL-2 | 160 (113; 223) | 226 (131; 259) | 0·31 |
| IL-4 | 208 (163; 246) | 245 (201; 302) | 0·18 |
| IL-5 | 214 (176; 277) | 298 (184; 351) | 0·71 |
| IL-10 | 163 (139; 243) | 224 (126; 244) | 0·68 |
All activation markers are given as medians (25%; 75% quartiles). Cytokine levels are given as medians (25%; 75% quartiles) of median fluorescence intensity (MFI). IFN, interferon; IL, interleukin; HLA-DR, human leucocyte antigen D-related.