Table 2.
Main and interactive effects of CFH + 1277 polymorphism and CRP haplotypes on carotid artery compliance (CAC) in males.
| CAC (%/10 mmHg) | Main effects of: | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Carriage of | CFH 402His carr+ | CFH 402His carr− | CRP† | CFH‡ | Interaction between loci | Observed power§ | ||||
| CRP haplotype | n | Mean (SE) | 95% CI | n | Mean (SE) | 95% CI | P¶ | P¶ | P¶ | % |
| ATGTG+ | 268 | 1·925 (0·037) | 1·853–1·998 | 134 | 2·034 (0·052) | 1·931–2·136 | 0·339 | 0·620 | 0·007 | 77·5 |
| ATGTG− | 197 | 2·104 (0·043) | 2·020–2·189 | 105 | 1·948 (0·059) | 1·832–2·064 | (0·037) | |||
| ACGCA+ | 252 | 2·041 (0·038) | 1·965–2·115 | 114 | 2·057 (0·057) | 1·948–2·171 | 0·033 | 0·978 | 0·718 | 6·5 |
| ACGCA− | 213 | 1·959 (0·042) | 1·873–2·036 | 125 | 1·939 (0·054) | 1·832–2·045 | (0·200) | |||
| GCGCG+ | 171 | 2·037 (0·046) | 1·943–2·124 | 106 | 2·074 (0·059) | 1·960–2·192 | 0·047 | 0·874 | 0·369 | 15·4 |
| GCGCG− | 291 | 1·983 (0·036) | 1·912–2·052 | 133 | 1·931 (0·053) | 1·830–2·036 | (0·500) | |||
| ACCCA+ | 49 | 2·060 (0·130) | 1·896–2·237 | 22 | 1·985 (0·087) | 1·737–2·236 | 0·747 | 0·639 | 0·650 | 8·1 |
| ACCCA− | 413 | 1·997 (0·041) | 1·935–2·052 | 217 | 1·995 (0·039) | 1·916–2·079 | (0·646) | |||
†
Haplotype carriage.
‡
Allele carriage.
§
Computed using α = 0·05.
¶
Adjustment with BMI, age, daily smoking, physical inactivity, LDL cholesterol and log triglycerides.
Values are presented after adjustment. Unadjusted P-values are presented in parentheses.